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主营:蛋白纯化试剂,血管和淋巴管研究试剂
℡ 4000-520-616
℡ 4000-520-616
ReliaTech/Human Follistatin like-protein 1/FSTL1 NEW/10-437/50 µg
产品编号:10-437
市  场 价:¥4896.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$244.80
品      牌: Relia Tech
公司分类:
ReliaTech/Human Follistatin like-protein 1/FSTL1 NEW/10-437/50 µg
商品介绍

Description:

Follistatin-likeprotein1(FSTL1)isawidely-expressed,extracellularglycoproteinthatishomologouslygroupedintotheosteonectin(BM-40/SPARC)familyofsecretedproteinsbasedonitspossessionofbothafollistatin-likeandextracellularcalcium-bindingdomain.InitiallyidentifiedasaTGF-beta-inducIBLeproteininaclonedmouseosteoblastcellline,FSTL1hassincebeenimplicatedinanarrayofcell-type-specificfunctions,suchastheregulationofproliferation,differentiation,apoptosisandmigration,aswellasanumberofBIOLOGicalprocesses,includingembryonicdevelopment,inflammatoryresponse,angiogenesis,tumOrigenesis,andimmunediseasepathogenesis.Highlyconservedacrossmammalianspeciesandwidelyexpressedinhumantissues,FSTL1canbeupregulatedthroughsignalingmediatorsoftheinnateimmunesystem,suchasTLR4agoNISTsandthearthritogeniccytokineIL-1betaviaNFκBpathways,tostimulatetheexpressionandsecretionofpro-inflammatorycytokines,includingTNF-alpha,IL-1beta,IL-6andIL-8.WhilecellsofmesenchymallineagearecapableofFSTL1production,FSTL1expressionisnotablyabsentfromcellsofhematopoieticlineageundernormalphysiologicalconditions.Macrophagesandmonocytesare,however,capableoftakingupFSTL1atsitesofinflammationwhereFSTL1stimulationcancausetheexpressionofcaspase-1anditsresultantenzymaticcleavageofactiveIL-1betafrompro-IL-1beta.WhereastheoverexpressionofFSTL1hasbeennotedasasubstantialcontributortotheprogressionofimmunediseaseslikerheumatoidarthritis(RA)andosteoarthritis(OA),diminishedFSTL1serumlevelshavebeenidentifiedasplayingasignificantpartinbothovarianandendometrialcarcinogenesis,whereitdirectlyaffectscellproliferation,migrationandinvasion.TheCHOcell-derivedrecombinanthumanFSTL1isa288-amino-acid-lengthglycoproteinwithacalculatedmolecularweightof32.7kDa;however,duetoglycosylation,proteinmigrationoccursatanapparentmolecularweightofapproximately50-55kDabySDS-PAGEanalysisunderbothreducingandnon-reducingconditions.
品牌介绍

ReliaTech


成立于1999年。除其他研究产品外,公司还开发、生产和销售用于血管生成和淋巴管生成研究的高质量研究试剂。


ReliaTech GmbH (short for Receptor Ligand Technologies GmbH) is a post-genomic German biotechnology company founded in 1999. Besides other research products the company develops, produces and sells high quality research reagents for angiogenic and lymphangiogenic research. 


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