Relia Tech/Mouse Anti-Human Angiopoietin-2 / Ang-2/100 µg/101-M102,Relia Tech,,Relia Tech,reliatech,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：Relia Tech/Mouse Anti-Human Angiopoietin-2 / Ang-2/100 µg/101-M102

产品编号：101-M102

市场价：¥5500.00

场地：美国(厂家直采)

产品分类：抗体类>一抗>单克隆抗体>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$275.00

品牌： Relia Tech

公司：Receptor Ligand Technologies GmbH

公司分类：

商品介绍

Cat-Nr.	101-M102
Size	100 µg
Price	275 €
Category	Monoclonal Antibody
Clone Nr.	(#1F29)
Isotype	IgG2
Species Reactivity	Human
Formulation	lyophilized
Buffer	PBS
Reconstitution	Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and Storage	Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Preparation	This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse immunized with purified human recombinant human Angiopoietin-2). The IgG2 fraction of the tissue culture supernatant was purified by Protein G affinity chromatography.
Antigen	recombinant human Angiopoietin-2
Application	WB, IHC (P)
Synonyms	ANGPT2; ANG2; AGPT2
Description	Angiopoietin2 (Ang2; also ANGPT2) is a secreted glycoprotein that plays a complex role in angiogenesis and inflammation. Mature Ang2 is 478 amino acids (aa) in length. It contains one coiledcoil domain (aa 166-248) that mediates multimerization, and a C-terminal fibrinogen like domain (aa 275-495) that mediates receptor binding. Under reducing conditions, secreted monomeric Ang2 is 65-66 kDa in size. Under nonreducing conditions, both natural and recombinant Ang2 form 140 kDa dimers, 200 kDa trimers, and 250-300 kDa tetramers and pentamers. Alternate splicing generates a short isoform that lacks 52 amino acids (aa) preceding the coiledcoil domain. Mature human Ang2 shares 86% aa sequence identity with mouse and rat Ang2. Ang2 is widely expressed during development, but it is restricted postnatally to highly angiogenic tissues such as the placenta, ovaries, and uterus. It is particularly abundant in vascular endothelial cells (EC) where it is stored in intracellular WeibelPalade bodies. Both Ang2 and the related Angiopoietin1 (Ang1) are ligands for the receptor tyrosine kinase Tie2. While Ang1 is a potent Tie2 agonist, Ang2 may act as either a Tie2 antagonist or agonist, depending upon its state of multimerization. The higher the order of oligomer, the more effective Ang2 becomes as a Tie2 agonist. The short isoform appears to block the binding of either Ang1 or full-length Ang2 to Tie2. Ang2 functions as a proangiogenic factor, although it can also induce EC death and vessel regression. Upon its release from quiescent EC, it regulates vascular remodeling by promoting EC survival, proliferation, and migration and destabilizing the interaction between EC and perivascular cells. Ang2 is required for postnatal vascular remodeling, and it cooperates with Ang1 during lymphatic vessel development. It mediates the upregulation of ICAM1 and VCAM1 on EC, which facilitates the adhesion of leukocytes during inflammation. Ang2 is upregulated in both the endothelium and tumor cells of several cancers as well as in ischemic tissue. Its direct interaction with Integrins promotes tumor cell invasion. Ang2 also promotes the neuronal differentiation and migration of subventricular zone progenitor cells.
Uniprot ID	Q15123
Protein RefSeq	NP_001138
mRNA RefSeq	NM_001147.2

品牌介绍

ReliaTech

成立于1999年。除其他研究产品外，公司还开发、生产和销售用于血管生成和淋巴管生成研究的高质量研究试剂。

ReliaTech GmbH (short for Receptor Ligand Technologies GmbH) is a post-genomic German biotechnology company founded in 1999. Besides other research products the company develops, produces and sells high quality research reagents for angiogenic and lymphangiogenic research.

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